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Dr. Konstantin Frank
Aesthetic medicine

SCIENCE-BASED REJUVENATION OF THE FACE AND THE BODY

By Dr. Konstantin Frank

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"HOW AGING PROCESSES INFLUENCE DECISION-MAKING ?"

Dr. Frank, when you talk about “science-based rejuvenation,” what do you mean?

Science-based rejuvenation means we base our interventions not on trends or anecdotal experience alone, but on a detailed understanding of the biological and structural changes that occur with aging. Aging is not a single process — it’s a choreography involving the skin, subcutaneous tissues, fascia, muscles, bones, vascular systems, and hormonal influences. Only by identifying which of these layers are most responsible for a patient’s changes can we design precise, safe, and longlasting treatments.

Could you walk us through what happens in the face and body as we age?

Certainly. In the skin and extracellular matrix (ECM), collagen I and III production drops, elastin fibers fragment, and natural moisturizing factors decline. This reduces strength, elasticity, and hydration, and photoaging accelerates this via chronic inflammation and enzymatic breakdown. Fat compartments — which are highly organized into superficial and deep layers — change in both volume and position. Some deep compartments deflate, like the temples and medial cheek, while others descend, as in the jowl or nasolabial area.

Deeper still, the fibrous septae, retaining ligaments, and fascial layers lose strength, and gliding planes stiffen. This unlocks the vector shifts we call ptosis and creates shadows like tear troughs and labiomental folds. Muscles adapt, sometimes becoming overactive in compensation — think of the frontalis lifting a drooping brow — while sarcopenia robs us of support and worsens posture. Bone remodeling reduces maxillary projection, widens the orbital aperture, and alters the jawline; dental changes reduce vertical height and lip support. Circulation and lymphatic drainage slow, “inflammaging” sets in, and hormonal changes such as menopause or andropause accelerate ECM loss and fat redistribution. All of this is why I say aging is both layered and regional — you can’t fix it by addressing one component in isolation.

How do you decide where to start with a patient?

I don’t start with their age; I start with their phenotype. Two people in their fifties may have completely different needs. I classify whether they are deflation predominant, descent-predominant, surface predominant, muscle-dominant, or experiencing structural support loss. Then I map these findings layer by layer — skin, fat, fascia, muscle, bone — and take photos in both neutral and expressive states.

What’s your guiding principle in treatment planning?

“Foundations first.” That means addressing bone structure, dentition, deep volume, and ligament support before moving to the skin envelope, and only then refining the details such as fine lines and pigment. If you start with the details, your results will be short lived. Sequencing is also critical: I begin with low-risk, high-benefit interventions such as photoprotection, barrier repair, and metabolic optimization. Then I layer in synergistic treatments — deep augmentation before superficial filler, collagen induction before pigment correction. And I always respect anatomical danger zones and have a complication plan.

How do you match the treatment to the specific problem?

A: For ECM decline, I might use retinoids, antioxidants, fractional lasers, RF microneedling, biostimulators, or platelet-derived preparations — sometimes hormone therapy when appropriate. Volume loss in deep compartments calls for deep-plane fat grafting or fillers; superficial loss requires delicate microbolus cannula injections. Ligament laxity may need lifting with surgery or devices. Muscle imbalance responds to carefully balanced neuromodulators. Skeletal and dental issues require interdisciplinary care. And with vascular or lymphatic stagnation, we avoid edema provoking procedures and support circulation.

Can you give us an overview of the different facial zones and how you approach them?

In the upper face — forehead, temple, brow, upper eyelid — the main issues are brow descent, temple hollowing, and orbital rim support loss. If brow descent is structural, neuromodulators alone can make heaviness worse, so we address support first. The midface ages through deep fat loss, malar descent, pyriform aperture resorption, and ligament laxity — here I restore deep cheek and zygomatic support before touching nasolabial folds. The lower face — perioral area, chin, jawline, neck — shows mandibular angle changes, jowls, perioral rhytids, and platysmal banding. Chin projection and jawline definition come from deep support; perioral lines respond best to collagen induction and resurfacing before filler; neck treatments depend on whether the main problem is skin, fat, muscle, or gland.

What about the body?

For the body, I look at skin quality and laxity first, particularly in sun-exposed areas like the neck, chest, hands, and forearms — these benefit from photoprotection, resurfacing, and biostimulatory treatments. Fat distribution changes, especially abdominal or flank fat linked to insulin resistance, are best addressed with a combination of contouring devices and lifestyle strategies. Muscle and fascia respond to resistance training and mobility work — in fact, training is the single most effective body aesthetic intervention over 6–12 months. For the hands and chest, volume restoration and pigment correction can make a big difference. Scars, stretch marks, and cellulite need mechanism-specific interventions, from dermal remodeling to septal release.

How important is prevention in your approach?

It’s essential. Daily broad-spectrum photoprotection is the highest-return anti-aging measure. Stable metabolic health, good sleep, adequate protein, micronutrient sufficiency, stress management — these all raise the ceiling for what we can achieve with interventions. Hormonal transitions must be anticipated and addressed proactively. And lifestyle factors like smoking, excessive alcohol, and pollution must be addressed; they can undo the benefits of even the most advanced treatments.

How do you ensure your treatments are ethical and safe?

We treat diagnoses, not just symptoms, and we work within each region’s risk tolerance. Patients are given staged plans with realistic timelines: months for skin improvement, immediate but evolving results for volume, instant lift with recovery time for surgery. We have protocols for every potential complication and a network of interdisciplinary colleagues — from dentistry to dermatology — to support outcomes.

If you had to summarise your philosophy in one sentence?

Science-based rejuvenation means identifying the true biological driver in each region, treating the right layer in the right sequence, and integrating local and systemic health — that’s how we achieve results that last, with patients who still look like themselves, only better supported.

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